Mother-infant stool, prenatal toxic element exposure
65 stool samples from a mother-infant cohort (longitudinal design), studying associations between prenatal nutrition-toxic element exposure and infant gut microbiome composition/diversity via 16S rRNA sequencing; country/age not reported. machine-written summary
65 samples · 65 runs · Infant / toddler · 2025 · 14.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 291 sample values (family id, family role, health condition, health condition detail, sex, subject id) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 130 sample values (collection date, location site) · PMC12137722 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolvedmother–infant
8 of 56 people sampled more than once (17 samples; median 2, up to 3 per person).
13 mother–child pairs with both sampled (43 family codes FB#; 26 mothers, 30 children) · 13 families with 26 sampled people (13 with a parent and a child).
motherchild · circles are people (pale = no sequenced sample), arrows run donor → recipient and parent → child, curved lines join twins, partners and siblings, squares are shared settings or families without recorded roles. Shown: 13 families. 56 people in the project overall.
Families (13)
| family | members | samples |
|---|---|---|
| FB25 | mother + child | SAMN44339783 · SAMN44339793 · SAMN44339810 · SAMN44339829 |
| FB7 | mother + child | SAMN44339780 · SAMN44339802 · SAMN44339811 · SAMN44339827 |
| FB11 | mother + child | SAMN44339804 · SAMN44339828 · SAMN44339840 |
| FB28 | mother + child | SAMN44339784 · SAMN44339794 · SAMN44339830 |
| FB36 | mother + child | SAMN44339785 · SAMN44339816 · SAMN44339834 |
| FB12 | mother + child | SAMN44339805 · SAMN44339812 |
| FB16 | mother + child | SAMN44339781 · SAMN44339813 |
| FB18 | mother + child | SAMN44339807 · SAMN44339841 |
| FB33 | mother + child | SAMN44339795 · SAMN44339832 |
| FB4 | mother + child | SAMN44339800 · SAMN44339839 |
| FB41 | mother + child | SAMN44339787 · SAMN44339835 |
| FB52 | mother + child | SAMN44339797 · SAMN44339837 |
| FB89 | mother + child | SAMN44339792 · SAMN44339825 |
Genera, mean relative abundance over 61 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 0 | 0% | ||||
| health_condition | 32 | 49% | 32 | |||
| subject_id | 65 | 100% | 65 | |||
| collection_date | 65 | 100% | 65 | |||
| detailed_location | 65 | 100% | ||||
| family_id | 65 | 100% | 65 | |||
| family_role | 65 | 100% | 65 | |||
| location_site | 65 | 100% | 65 | |||
| health_condition_detail | 32 | 49% | 32 | |||
| sex | 32 | 49% | 32 |
- Prenatal exposure to trace elements impacts mother-infant gut microbiome, metabolome and resistome during the first year of life. PMID 40467587 PMC12137722 curated
Archive description
The gut microbiome is considered to be the "second brain" of the human body and plays an important role in human health, which is influenced by the mode of delivery , feeding regimen, dietary structure, antibiotics, and environmental factors, etc. Early life is a critical window for the colonization and development of the human gut microbiome. Investigating the effects of prenatal exposure to nutrition-toxic elements on the colonization and development of the gut microbiome in early life may provide a scientific basis for using the gut microbiome as a target organ for long-term, low-dose exposure to environmental chemicals. The main objective of this study was to explore the association between prenatal exposure to nutrition-toxic element on the composition and diversity of the infant gut microbiome and its dynamics. The exploration of associations combined linear regression model, permutational multivariate analysis of variance and linear discriminant analysis effect size.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and adult by sonnet_x2 with confidence 0.65. Assay shotgun_dna.
- host study.title · “paired mother-infant”
- host run.host_tax_id · “9606”
- body site study.title · “stool sample of paired mother-infant”
- body site run.scientific_name · “gut metagenome”
- life stage study.description · “colonization and development of the human gut microbiome in early life”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN44339780 | collection_date | 2021-11/2023-03 | R3 | 0.70 | paper.fulltext.methods | recruited between November 2021 and March 2023 |
| SAMN44339780 | family_id | FB7 | R1 | 0.70 | run.library_name | MGS_M_FB7 |
| SAMN44339780 | family_role | mother | R1 | 0.70 | run.library_name | MGS_M_FB7 |
| SAMN44339780 | health_condition | pregnancy_postpartum | R1 | 0.70 | sample.name_rule:library_names | MGS_M_FB7 |
| SAMN44339780 | health_condition_detail | MGS_M_FB7 | R1 | 0.70 | sample.name_rule:library_names | MGS_M_FB7 |
| SAMN44339780 | location_site | Peking University People's Hospital | R3 | 0.70 | paper.fulltext.methods | conducted by Peking University People's Hospital |
| SAMN44339780 | sex | female | R1 | 0.70 | sample.name_rule:library_names | MGS_M_FB7 |
| SAMN44339780 | subject_id | M_FB7 | R1 | 0.70 | sample.name_rule:library_names | MGS_M_FB7 |
Sequencing
65 runs over 65 samples · mean 14.39 Gbp per run (median 14.14 Gbp, total 935.54 Gbp; 65 runs with a base count) · layout PAIRED 65 · platform ILLUMINA 65 · models Illumina NovaSeq X Plus (65) · 94% of runs with a Sandpiper profile · first public 2025-05-01
Authors (13)
Xiong S first · Xie B · Yin N · Zhu H · Gao H · Xu X · Xiao K · Cai X · Sun G · Sun X · Cui Y · Van de Wiele T · Zhu Y last
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, country, health_condition. Share metadata
Downloads
PRJNA986854.csv.gz (3.1 KB) · parquet (74.0 KB) — all 65 samples, every field with route and confidence · PRJNA986854_determinations.csv.gz (4.5 KB) — 421 evidence rows