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PRJNA999635 SRP451978

Gut microbiome and social networks in rural Honduras

Gut Microbiome of isolated villages in rural Honduras

Cross-sectional study of 1,889 gut microbiome samples from isolated villages in Copan, Honduras, examining how social network structure relates to species- and strain-level microbiome composition and sharing among adults. machine-written summary

1,889 samples · 1,889 runs · HN · Age unknown · 2023 · 12.09 Gbp / sample

Sources
✓Sequence archive 5,667✓Abstract / description 3,778○Full text○Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive5,667 sample values (collection date, country, location locality)
✓ Abstract / description3,778 sample values (lifestyle, lifestyle detail)
○ Full textread; no usable statement or table · PMC10645880, PMC11290354, PMC11666459, PMC12534905, PMC12636519, PMC12867399
○ Supplementary tablesfiles read; no table could be matched to the samples
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet · share metadata
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 country
Age
unknown1,889
Country
HN1,889
Body site
primary1,889
Collected 2020–2022
2020: 448 samples2021: 945 samples2022: 496 samples20202022
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 2 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 262 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 1,611 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)this project, 30–100 Gbp: 14 samplesall projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 12.09 Gbp per sample0130Gbp
Sampling design and relatedness

community — not resolved

1,889 adults sampled across multiple isolated villages in Copan, Honduras; study examines social-network-linked microbiome sharing..

How longitudinal and relatedness information is derived

Community composition
Prevotella 43.8%Roseburia 2.8%Treponema_D 2.4%Alloprevotella 2.3%Cryptobacteroides 2.1%Succinivibrio 2.0%Faecalibacterium 1.8%Dialister 1.7%Acetatifactor 1.6%Vescimonas 1.5%Ruminococcoides 1.5%Eshraghiella 1.0%not assigned to a genus 3.1%other genera 32.5%

Genera, mean relative abundance over 1,719 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category0 0%
country1,889 100%1,889
health_condition0 0%
subject_id0 0%
collection_date1,889 100%1,889
detailed_location1,889 100%
lifestyle1,889 100%1,889
lifestyle_detail1,889 100%1,889
location_locality1,889 100%1,889
Papers (6)
  • Environmental, socioeconomic, and health factors associated with gut microbiome species and strains in isolated Honduras villages. 2024 PMID 38968070 PMC11290354 own_data
  • Gut microbiome strain-sharing within isolated village social networks. 2025 PMID 39567691 PMC11666459 own_data
  • Enhancing genome recovery across metagenomic samples using MAGmax. 2025 PMID 41002272 PMC12534905 own_data
  • Evaluation of metagenome binning: advances and challenges. 2025 PMID 41269281 PMC12636519 own_data
  • Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide. 2023 PMID 37963868 PMC10645880 unsure
1 more
  • Socioeconomic position and the gut microbiota: a narrative synthesis of the association and recommendations. 2026 PMID 41620643 PMC12867399
Details
Archive description

Gut Microbiome of isolated villages in rural Honduras

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.72. Assay shotgun_dna.

  • host run.host_tax_id · “9606”
  • body site study.title · “Gut Microbiome of isolated villages”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN36744534collection_date2020-02-21R10.90biosample.attribute:collection_date2020-02-21
SAMN36744534countryHNR10.90sample.attr.geo_loc_nameHonduras:Copan
SAMN36744534lifestylerural_non_industrializedR40.50paper.abstract19 isolated villages in the Mesoamerican highlands
SAMN36744534lifestyle_detailisolated villages, Mesoamerican highlands, western HondurasR40.50paper.abstract19 isolated villages in the Mesoamerican highlands
SAMN36744534location_localityCopanR10.85biosample.attribute:geo_loc_nameHonduras:Copan
Sequencing

1,889 runs over 1,889 samples · mean 12.45 Gbp per run (median 12.09 Gbp, total 23,520.07 Gbp; 1,889 runs with a base count) · layout PAIRED 1,889 · platform ILLUMINA 1,889 · models Illumina NovaSeq 6000 (1,889) · 91% of runs with a Sandpiper profile · first public 2023-10-02 – 2025-12-21

Authors (31)

Diebold PJ first · Rhee MW · Shi Q · Trung NV · Umrani F · Ahmed S · Kulkarni V · Deshpande P · Alexander M · Thi Hoa N · Christakis NA · Iqbal NT · Ali SA · Mathad JS · Brito IL last · Shridhar SV first · Beghini F · Singh A · Juárez RM · Yazhini A first · Söding J last · Morice · Jochheim A · Lieser B · Ratcliff JS first · Kumari M · Varga-Weisz P · O'Gorman R last · Schroer HW first · Raygoza Garay JA · Bosch DE last

Help complete this project

3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata

Downloads

PRJNA999635.csv.gz (44.4 KB) · parquet (135.7 KB) — all 1,889 samples, every field with route and confidence · PRJNA999635_determinations.csv.gz (49.5 KB) — 9,445 evidence rows

Samples (1,889 · every field this project has values for · hover a cell for its source)
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