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Colorectal cancer meta-analysis cohorts (Wirbel / Thomas 2019)
Disease reference sets · collection id crc-meta-analysis-cohorts
The eight case–control shotgun cohorts pooled by Wirbel et al. and Thomas et al. (Nature Medicine 2019): France, Austria, Germany, China, USA, two Italian cohorts and Japan — the standard benchmark for cross-cohort CRC classifiers.
Open in the sample explorer (1,641 samples)
8
studies with member samples
1,641
member samples in this release
Membership rule
| Studies | PRJEB6070, PRJEB7774, PRJEB27928, PRJEB10878, PRJEB12449, PRJNA447983, PRJDB4176, PRJNA389927 |
Hannigan 2018 (PRJNA389927) is the US cohort used by Thomas et al.; Vogtmann 2016 (PRJEB12449) the US cohort used by Wirbel et al.
Composition
Age category
| adult | 898 |
| elderly | 638 |
| unknown | 105 |
Country
| JP | 645 |
| US | 234 |
| FR | 156 |
| AT | 156 |
| IT | 140 |
| CN | 128 |
Health condition
| healthy_control Healthy / control | 620 |
| colorectal_cancer Colorectal cancer | 513 |
| colorectal_adenoma Colorectal adenoma / polyp | 244 |
| other_cancer Other cancer (incl. immunotherapy cohorts) | 187 |
Member studies (8)
| Study | Title | Member samples | First public |
|---|---|---|---|
| PRJDB4176 | metagenomic data from human fecal samples | 645 | 2019 |
| PRJEB6070 | Potential of fecal microbiota for early stage detection of colorectal cancer | 199 | 2014 |
| PRJNA389927 | Viral and Bacterial Communities of Colorectal Cancer | 181 | 2017 |
| PRJEB7774 | Gut microbiome development along the colorectal adenoma-carcinoma sequence | 156 | 2015 |
| PRJNA447983 | Whole-metagenome shotgun sequencing of two Italian fecal CRC cohorts | 140 | 2018 |
| PRJEB10878 | Metagenomic analysis of fecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer | 128 | 2015 |
| PRJEB12449 | Reproducibility of associations between the human gut microbiome and colorectal cancer assessed in a patient population from Washington, DC, USA | 110 | 2016 |
| PRJEB27928 | Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. | 82 | 2018 |