FMT trial in men with metabolic syndrome, Netherlands
130 fecal metagenome samples from a Dutch randomized controlled trial of allogenic versus autologous fecal microbiota transplantation in male patients with metabolic syndrome, with longitudinal sampling. machine-written summary
130 samples · 260 runs · NL · Adult · 2022 · 6.47 Gbp / sample · cohort Drivers and determinants of strain dynamics follow
One study deposited as 2 BioProjects (185 catalog samples together): PRJEB12357 · PRJEB46778 · show together
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 659 sample values (collection date, country, latitude, longitude, subject id, timepoint) |
| ✓ Abstract / description | 32 sample values (health condition, health condition detail) |
| ○ Full text | read; no usable statement or table · PMC9499871 |
| ✓ Supplementary tables | 648 sample values (age, health condition, health condition detail, intervention, sex, timepoint) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
26 people have samples in more than one arm.
Faecal microbiota transplantation design randomized_controlled_trial · population cardiometabolic_other · Lean donor (allogenic) vs autologous FMT in metabolic syndrome patients
“lean donor (allogenic) versus own (autologous) fecal microbiota transplantation” — abstract:28978426 (study level; per-sample arms are in the intervention column below)
longitudinalFMT donor → recipient — not resolved
27 of 40 people sampled more than once (117 samples; median 4, up to 5 per person) · follow-up median 4 mo (max 5 mo) · median interval between samples 28 d (time from collection dates). Schedule stated by the source: “Stool at days 0, 2, 14, 21, 42, 84 and 126 after FMT” (time origin: transplant); stated follow-up 4 mo.
Each row is one person (26 shown of 27); dots are samples at days since that person's first sample.
FMT RCT in metabolic syndrome; 14 donor stool samples (FAT_DON / FATLOSE_DON) and 26 recipients sampled over time; donor→recipient links not committed.
Genera, mean relative abundance over 130 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 130 | 100% | ||||
| country | 130 | 100% | 130 | |||
| health_condition | 130 | 100% | 114 | 16 | ||
| subject_id | 130 | 100% | 130 | |||
| collection_date | 130 | 100% | 130 | |||
| health_condition_detail | 130 | 100% | 114 | 16 | ||
| latitude | 130 | 100% | 130 | |||
| longitude | 130 | 100% | 130 | |||
| timepoint_label | 130 | 100% | 9 | 121 | ||
| sex | 121 | 93% | 121 | |||
| intervention | 114 | 88% | 114 | |||
| age_at_collection_days | 64 | 49% | 64 |
- Durable coexistence of donor and recipient strains after fecal microbiota transplantation. 2016 PMID 27126044 own_data
- Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. 2017 PMID 28978426 own_data
- Drivers and determinants of strain dynamics following fecal microbiota transplantation. 2022 PMID 36109636 PMC9499871 unsure
Archive description
Longitudinal metagenomic sequencing data for a Randomized-Controlled Trial of Fecal Microbiota Transplantation in patients with metabolic syndrome. Extension to a previous dataset (PRJEB12357), described by Li et al, 2016 (PMID:27126044) and Koote et al, 2017 (PMID:28978426).
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Fecal Microbiota Transplantation for”
- body site study.description · “Randomized-Controlled Trial of Fecal Microbiota Transplantation in”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA9457639 | age_at_collection_days | 22207.0 | R2 | 0.75 | paper.supp.41591_2022_1913_MOESM3_ESM.xlsx[S3_metadata!age_years] | subject_id=FATLOSE002; age_years=60.8 |
| SAMEA115160322 | collection_date | 2009-03-11 | R1 | 0.90 | biosample.attribute:collection_date | 2009-03-11 |
| SAMEA115160322 | country | NL | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Netherlands |
| SAMEA115160322 | health_condition | cardiometabolic_other | R2 | 0.75 | paper.supp.41591_2022_1913_MOESM3_ESM.xlsx[S2_FMT!indication] | subject.recipient=FAT_008; indication=metabolic_syndrome |
| SAMEA115160372 | health_condition | cardiometabolic_other | R4 | 0.50 | study.description | patients with metabolic syndrome |
| SAMEA115160322 | health_condition_detail | metabolic_syndrome | R2 | 0.75 | paper.supp.41591_2022_1913_MOESM3_ESM.xlsx[S2_FMT!indication] | subject.recipient=FAT_008; indication=metabolic_syndrome |
| SAMEA115160372 | health_condition_detail | Metabolic syndrome patients in FMT trial | R4 | 0.50 | study.description | patients with metabolic syndrome |
| SAMEA115160322 | intervention | no_intervention | R2 | 0.75 | paper.supp.41591_2022_1913_MOESM3_ESM.xlsx[S3_metadata!subject_type] | subject_id=FAT_008; subject_type=recipient |
| SAMEA115160322 | latitude | 52.0000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 52.0 5.0 |
| SAMEA115160322 | longitude | 5.0000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 52.0 5.0 |
| SAMEA115160322 | sex | male | R2 | 0.75 | paper.supp.41591_2022_1913_MOESM3_ESM.xlsx[S3_metadata!sex] | subject_id=FAT_008; sex=male |
| SAMEA115160322 | subject_id | FAT_008 | R1 | 0.70 | sample.name_rule:sample_title | FAT_008-22-0-0 |
| SAMEA115160372 | timepoint_label | 0 | R1 | 0.70 | sample.name_rule:sample_title | FAT_DON_11-22-0-4 |
| SAMEA115160322 | timepoint_label | 0 | R2 | 0.75 | paper.supp.41591_2022_1913_MOESM3_ESM.xlsx[S3_metadata!timepoint] | subject_id=FAT_008; timepoint=0 |
Sequencing
260 runs over 130 samples · mean 3.15 Gbp per run (median 2.87 Gbp, total 818.55 Gbp; 260 runs with a base count) · layout PAIRED 130, SINGLE 130 · platform ILLUMINA 260 · models Illumina HiSeq 4000 (150), Illumina HiSeq 2000 (110) · 90% of runs with a Sandpiper profile · first public 2022-04-28 – 2024-01-29
Authors (55)
Li SS first · Zhu A · Benes V · Costea PI · Hercog R · Hildebrand F · Huerta-Cepas J · Nieuwdorp M · Salojärvi J · Voigt AY · Zeller G · Sunagawa S · de Vos WM · Bork P last · Kootte RS first · Levin E · Smits LP · Hartstra AV · Udayappan SD · Hermes G · Bouter KE · Koopen AM · Holst JJ · Knop FK · Blaak EE · Zhao J · Smidt H · Harms AC · Hankemeijer T · Bergman JJGHM · Romijn HA · Schaap FG · Olde Damink SWM · Ackermans MT · Dallinga-Thie GM · Zoetendal E · Serlie MJ · Stroes ESG · Groen AK · Schmidt TSB first · Maistrenko OM · Akanni W · Coelho LP · Dolai S · Fullam A · Glazek AM · Herrema H · Jung F · Kandels S · Orakov A · Thielemann R · von Stetten M · Van Rossum T · Borody TJ · Ponsioen CY
Downloads
PRJEB46778.csv.gz (5.0 KB) · parquet (77.0 KB) — all 130 samples, every field with route and confidence · PRJEB46778_determinations.csv.gz (11.3 KB) — 1,339 evidence rows