Fecal microbiome in decompensated cirrhosis/ACLF, Europe
Cross-sectional study of 173 fecal samples from adult patients with cirrhosis and acute decompensation or acute-on-chronic liver failure, collected across 48 hospitals in 10 European countries (MICROB-PREDICT project). machine-written summary
173 samples · 173 runs · IT, DE, ES · Adult · 2025 · 6.48 Gbp / sample · cohort <i>L</i> <i>actococcus A</i&g
One study deposited as 2 BioProjects (475 catalog samples together): PRJEB89898 · PRJEB89899 · show together
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,205 sample values (collection date, country, health condition, health condition detail, sex, subject id, timepoint) |
| ✓ Abstract / description | 6 sample values (health condition, health condition detail) |
| ○ Full text | read; no usable statement or table · PMC12721046 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 171 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 173 | 100% | ||||
| country | 173 | 100% | 173 | |||
| health_condition | 173 | 100% | 170 | 3 | ||
| subject_id | 173 | 100% | 173 | |||
| collection_date | 173 | 100% | 173 | |||
| health_condition_detail | 173 | 100% | 170 | 3 | ||
| sex | 173 | 100% | 173 | |||
| timepoint_label | 173 | 100% | 173 |
- <i>L</i> <i>actococcus A</i> phages predict ACLF while <i>Enterococcus B</i> phages predict bacterial infection in decompensated cirrhosis. 2026 PMID 41438339 PMC12721046 own_data
Archive description
This is a prospective, observational, multicenter study involving 48 hospitals across Europe. The institutional review board at each participating center approved the study protocol. Patients with cirrhosis, diagnosed via previous liver biopsy or a combination of clinical signs and findings from laboratory tests, endoscopy, and ultrasonography, were included. The criteria for diagnosing acute decompensation upon hospitalisation included the development of ascites, hepatic encephalopathy, infection, gastrointestinal haemorrhage, or a combination of these conditions. Acute-on-chronic liver failure (ACLF) diagnosis during follow-up was conducted according to the study criteria from CANONIC (Moreau et al., 2013). The dysfunction and failure of organs were defined using the organ failure score (Jalan et al., 2014) from the CLIF consortium (CLIF-C). This study was conducted within the MICROB-PREDICT project.
How this project entered the registry
Classified as human gut / stool / blood / tissue / internal fluids shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “sequences of the fecal microbiome from patients”
- body site study.description · “hepatic encephalopathy, infection, gastrointestinal haemorrhage, or a”
- body site study.description · “diagnosed via previous liver biopsy or a”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA118785551 | collection_date | 2017 | R1 | 0.90 | biosample.attribute:collection_date | 2017 |
| SAMEA118785551 | country | DE | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Germany |
| SAMEA118785551 | health_condition | liver_disease | R1 | 0.90 | biosample_attr | stable decompensated cirrhosis |
| SAMEA118785554 | health_condition | liver_disease | R4 | 0.50 | paper.abstract | acute decompensation of cirrhosis and acute-on-chronic liver failure (ACLF) |
| SAMEA118785551 | health_condition_detail | stable decompensated cirrhosis | R1 | 0.90 | sample.attr.disease_status | stable decompensated cirrhosis |
| SAMEA118785554 | health_condition_detail | cirrhosis | R4 | 0.50 | paper.abstract | acute decompensation of cirrhosis and acute-on-chronic liver failure (ACLF) |
| SAMEA118785551 | sex | male | R1 | 0.90 | sample.attr.host_sex | Male |
| SAMEA118785551 | subject_id | SP-MI-TR89M | R1 | 0.85 | sample.attr.subject_id | SP-MI-TR89M |
| SAMEA118785551 | timepoint_label | 0 | R1 | 0.85 | sample.attr.days_from_first_visit | 0 |
Sequencing
173 runs over 173 samples · mean 6.39 Gbp per run (median 6.48 Gbp, total 1,106.07 Gbp; 173 runs with a base count) · layout PAIRED 173 · platform ILLUMINA 173 · models Illumina HiSeq 4000 (173) · 99% of runs with a Sandpiper profile · first public 2025-07-30
Authors (0)
No author record.
Downloads
PRJEB89899.csv.gz (6.6 KB) · parquet (78.2 KB) — all 173 samples, every field with route and confidence · PRJEB89899_determinations.csv.gz (8.8 KB) — 1,211 evidence rows