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PRJNA1372073 SRP650322

Gut Metagenomics in HCC vs CRLM Patients, China

Hepatocellular Carcinoma Cohort Metagenomics

Shotgun metagenomic study of 57 catalogued stool samples from Chinese patients with hepatocellular carcinoma (n=52) and colorectal liver metastases (n=5), part of a larger HCC cohort study. machine-written summary

57 samples · 57 runs · CN · Age unknown · 2026 · 13.59 Gbp / sample · cohort Two stable gut microbiome guilds predict liver tum

One study deposited as 2 BioProjects (254 catalog samples together): PRJNA1372070 · PRJNA1372073 · show together

Sources
✓Sequence archive 171✓Abstract / description 57✓Full text 57✓Supplementary tables 114–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive171 sample values (collection date, country, location locality)
✓ Abstract / description57 sample values (location region)
✓ Full text57 sample values (location site) · PMC13147943
✓ Supplementary tables114 sample values (health condition, health condition detail)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet · share metadata
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 country
Age
unknown57
Condition
liver_disease52
colorectal_cancer5
Country
CN57
Body site
primary57
Collected 2024–2025
2024: 12 samples2025: 45 samples20242025
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)all projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 57 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 13.59 Gbp per sample0130Gbp
Community composition

No Sandpiper profile for this project's samples yet.

Field coverage
fieldsamplescoverageR1R2R3R4
age_category0 0%
country57 100%57
health_condition57 100%57
subject_id0 0%
collection_date57 100%57
detailed_location57 100%
health_condition_detail57 100%57
location_locality57 100%57
location_region57 100%57
location_site57 100%57
Papers (1)
  • Two stable gut microbiome guilds predict liver tumor class and treatment responses. 2026 PMID 42099457 PMC13147943 own_data
Details
Archive description

Hepatocellular Carcinoma Cohort from No.2 Hospital of Ningbo, China.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of age unknown by curator_audit with confidence 0.45. Assay shotgun_dna.

  • host runs.scientific_name · “human gut metagenome”
  • host runs.isolation_source · “feces”
  • body site runs.scientific_name · “human gut metagenome”
  • body site runs.isolation_source · “feces”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN53528796collection_date2024-11-07R10.85biosample.attribute:collection_date2024-11-07
SAMN53528796countryCNR10.90sample.attr.geo_loc_nameChina: Ningbo
SAMN53528796health_conditionliver_diseaseR20.85paper.supp.IMT2-5-e70123-s001.xlsx[S8!HCC/CRLM]HF38 HCC
SAMN53528796health_condition_detailhepatocellular carcinoma (HCC)R20.85paper.supp.IMT2-5-e70123-s001.xlsx[S8!HCC/CRLM]HF38 HCC
SAMN53528796location_localityNingboR10.85biosample.attribute:geo_loc_nameChina: Ningbo
SAMN53528796location_regionZhejiangR40.45ena.study_descriptionNo.2 Hospital of Ningbo, China
SAMN53528796location_siteNingbo No.2 HospitalR30.70paper.body.methodsdiagnosed and treated at Ningbo No. 2 Hospital
Sequencing

57 runs over 57 samples · mean 13.70 Gbp per run (median 13.59 Gbp, total 780.95 Gbp; 57 runs with a base count) · layout PAIRED 57 · platform HELICOS 57 · models Helicos HeliScope (57) · 0% of runs with a Sandpiper profile · first public 2026-03-22

Authors (0)

No author record.

Help complete this project

2 of the 4 core fields are below 50% coverage: age_category, subject_id. Share metadata

Downloads

PRJNA1372073.csv.gz (2.5 KB) · parquet (72.0 KB) — all 57 samples, every field with route and confidence · PRJNA1372073_determinations.csv.gz (3.6 KB) — 399 evidence rows

Samples (57 · every field this project has values for · hover a cell for its source)
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