Gut microbiome, warfarin after heart valve replacement
15 fecal samples from adult and elderly inpatients (post heart valvular replacement) receiving warfarin, comparing low, high, and control responders in a case-control design to explore microbiome links to warfarin dosage. machine-written summary
15 samples · 15 runs · Adult · 2020 · 0.24 Gbp / sample
One study deposited as 2 BioProjects (16 catalog samples together): PRJNA520743 · PRJNA520777 · show together
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 60 sample values (age, intervention, sex, subject id) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design observational_with_procedure · population cardiometabolic_other · Heart valvular replacement surgery; warfarin therapy dosing comparison (low vs high vs control responders)
“early inpatients after implementing heart valvular replacement” — bioproject.description (study level; per-sample arms are in the intervention column below)
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 15 | 100% | ||||
| country | 0 | 0% | ||||
| health_condition | 0 | 0% | ||||
| subject_id | 15 | 100% | 15 | |||
| age_at_collection_days | 15 | 100% | 15 | |||
| intervention | 15 | 100% | 15 | |||
| sex | 15 | 100% | 15 |
- The gut microbiome affects the responses of heart valve replacement patients to the anticoagulant warfarin 2020 own_data
Archive description
To characterize gut microbiome in early inpatients after implementing heart valvular replacement(HVR) and compare the fecal microbiota composition and functionality among low warfarin responders (LR),high warfarin responders (HR) and control warfarin responders (CONTROL),then evaluate the potential of microbiome as factors in modulating the dosage of warfarin for preventing GI bleeding and thromboembolic events.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by opus_adjudicated with confidence 0.80. Assay shotgun_dna.
- host study.title · “patients receiving warfarin therapy”
- body site study.description · “compare the fecal microbiota composition”
- life stage sample.attr.age · “60 (n=9/15)”
- life stage sample.attr.age · “66 (n=6/15)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN10867463 | age_at_collection_days | 18614.0 | R1 | 0.85 | sample.attr.age | 51 |
| SAMN10867463 | intervention | drug_therapy | R1 | 0.70 | sample.name_rule:alias | LR-1 |
| SAMN10867463 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN10867463 | subject_id | HLP | R1 | 0.70 | biosample.attribute:biomaterial_provider | biomaterial_provider: HLP (alias LR-1) |
Sequencing
15 runs over 15 samples · mean 0.25 Gbp per run (median 0.24 Gbp, total 3.69 Gbp; 15 runs with a base count) · layout PAIRED 15 · platform ILLUMINA 15 · models Illumina MiSeq (15) · 0% of runs with a Sandpiper profile · first public 2020-08-16
Authors (0)
No author record.
Downloads
PRJNA520777.csv.gz (1.4 KB) · parquet (69.6 KB) — all 15 samples, every field with route and confidence · PRJNA520777_determinations.csv.gz (1.3 KB) — 60 evidence rows