Gut microbiome in MASLD liver steatosis, Sweden
Shotgun metagenomic sequencing of 66 stool samples from a Swedish cohort collected in 2014, examining gut microbiome profiles associated with simple liver steatosis in MASLD. machine-written summary
66 samples · 66 runs · SE · Adult · 2026 · 6.34 Gbp / sample
One study deposited as 3 BioProjects (134 catalog samples together): PRJEB120967 · PRJEB120968 · PRJEB120969 · show together
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 132 sample values (collection date, country) |
| ✓ Abstract / description | 132 sample values (antibiotic exposure, location region) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 66 | 100% | ||||
| country | 66 | 100% | 66 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 66 | 100% | 66 | |||
| collection_date | 66 | 100% | 66 | |||
| detailed_location | 66 | 100% | ||||
| location_region | 66 | 100% | 66 |
Archive description
This study contains whole-genome shotgun metagenomic sequencing data from faecal samples collected in the Swedish cohort of the study “Gut microbiome profiles associated with simple liver steatosis in MASLD”. The cohort includes adults with ultrasound-diagnosed liver steatosis and geographically matched controls without steatosis. Individuals with evidence of advanced liver disease, recent antibiotic use, proton pump inhibitor use, metformin use, or other relevant exclusion criteria were not included in the analysis. The aim of the study was to characterize gut microbiota composition and functional potential in simple steatosis, the earliest clinically relevant stage of metabolic dysfunction-associated steatotic liver disease (MASLD), while minimizing confounding by common medications. These data were analysed together with independent Austrian and Italian cohorts to assess microbiome signatures associated with simple steatosis across European populations spanning a broad range of body mass index.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.90. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.description · “faecal samples collected in the Swedish cohort”
- life stage study.description · “adults with ultrasound-diagnosed liver steatosis”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA123173399 | antibiotic_exposure | no | R4 | 0.50 | study.description | Individuals with evidence of advanced liver disease, recent antibiotic use |
| SAMEA123173399 | collection_date | 2014 | R1 | 0.85 | biosample.attribute:collection_date | 2014 |
| SAMEA123173399 | country | SE | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Sweden |
| SAMEA123173399 | location_region | Sweden | R4 | 0.40 | ena.study_title | Swedish cohort |
Sequencing
66 runs over 66 samples · mean 6.24 Gbp per run (median 6.34 Gbp, total 411.84 Gbp; 66 runs with a base count) · layout PAIRED 66 · platform ILLUMINA 66 · models NextSeq 500 (66) · 0% of runs with a Sandpiper profile · first public 2026-09-29
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJEB120968.csv.gz (2.4 KB) · parquet (71.8 KB) — all 66 samples, every field with route and confidence · PRJEB120968_determinations.csv.gz (1.8 KB) — 264 evidence rows