Gut microbiome in GD patients, Haikou, China (case-control)
20 gut metagenome samples from adults in Haikou, China, comparing GD patients to 17 healthy controls in a case-control design examining ecological and evolutionary microbiome changes. machine-written summary
20 samples · 20 runs · CN · Adult · 2020 · 8.46 Gbp / sample
One study deposited as 6 BioProjects (164 catalog samples together): PRJNA602729 · PRJNA602731 · PRJNA602732 · PRJNA638403 · PRJNA638404 · PRJNA638405 · show together
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 148 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC10734426, PMC11954268, PMC8528855 |
| ✓ Supplementary tables | 49 sample values (age, bmi, sex, smoking status, subject id) |
| ✓ External resources | 51 sample values (age, bmi, sex) · from Meta2DB (LLNL) |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 19 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 20 | 100% | ||||
| country | 20 | 100% | 20 | |||
| health_condition | 20 | 100% | 20 | |||
| subject_id | 20 | 100% | 20 | |||
| age_at_collection_days | 20 | 100% | 20 | |||
| bmi | 20 | 100% | 20 | |||
| collection_date | 20 | 100% | 20 | |||
| detailed_location | 20 | 100% | ||||
| health_condition_detail | 20 | 100% | 20 | |||
| latitude | 20 | 100% | 20 | |||
| location_locality | 20 | 100% | 20 | |||
| longitude | 20 | 100% | 20 | |||
| sex | 20 | 100% | 20 | |||
| smoking_status | 20 | 100% | 20 | |||
| location_region | 8 | 40% | 8 |
- Compositional and genetic alterations in Graves' disease gut microbiome reveal specific diagnostic biomarkers. 2021 PMID 34079079 PMC8528855 unsure
- Cross-cohort single-nucleotide-variant profiling of gut microbiota suggests a novel gut-health assessment approach. 2023 PMID 37905808 PMC10734426 unsure
- Modeling microbiome-trait associations with taxonomy-adaptive neural networks. 2025 PMID 40158141 PMC11954268 unsure
Archive description
Ecological and evolutionary alteration in the intestinal microbiome of GD patients
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.65. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
- life stage study.title · “GD intestinal microbiome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN15195411 | age_at_collection_days | 16071.0 | R2 | 0.70 | external.meta2db source | host_age: 44 |
| SAMN15195413 | age_at_collection_days | 13514.0 | R2 | 0.85 | paper.supp.41396_2021_1016_MOESM2_ESM.xlsx[Table_S1!Age] | C03 | Age: 37 |
| SAMN15195411 | bmi | 21.09 | R2 | 0.70 | external.meta2db source | host_body_mass_index: 21.09 kilogram per meter squared |
| SAMN15195413 | bmi | 21.09 | R2 | 0.85 | paper.supp.41396_2021_1016_MOESM2_ESM.xlsx[Table_S1!BMI] | C03 | BMI: 21.09 |
| SAMN15195411 | collection_date | 2018-07 | R1 | 0.90 | biosample.attribute:collection_date | 2018-07 |
| SAMN15195411 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Haikou |
| SAMN15195411 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:TITLE | HC metagenome |
| SAMN15195411 | health_condition_detail | HC metagenome | R1 | 0.85 | biosample.attribute:TITLE | HC metagenome |
| SAMN15195411 | latitude | 20.0300 | R1 | 0.90 | biosample.attribute:lat_lon | 20.03 N 110.10 E |
| SAMN15195411 | location_locality | Haikou | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Haikou |
| SAMN15195419 | location_region | Hainan | R1 | 0.60 | biosample.attribute:lat_lon | 20.03 N 110.18 E |
| SAMN15195411 | longitude | 110.1000 | R1 | 0.90 | biosample.attribute:lat_lon | 20.03 N 110.10 E |
| SAMN15195411 | sex | female | R2 | 0.70 | external.meta2db source | host_sex: female |
| SAMN15195413 | sex | male | R2 | 0.85 | paper.supp.41396_2021_1016_MOESM2_ESM.xlsx[Table_S1!Gender] | C03 | Gender: M |
| SAMN15195411 | smoking_status | never | R2 | 0.85 | paper.supp.41396_2021_1016_MOESM2_ESM.xlsx[Table_S1!Smoking] | C01 | Smoking: NO |
| SAMN15195411 | subject_id | C001 | R2 | 0.85 | paper.supp.41396_2021_1016_MOESM2_ESM.xlsx[Table_S1!col0] | C01 | col0: C001 |
Sequencing
20 runs over 20 samples · mean 8.58 Gbp per run (median 8.46 Gbp, total 171.60 Gbp; 20 runs with a base count) · layout PAIRED 20 · platform ILLUMINA 20 · models Illumina HiSeq 4000 (20) · 95% of runs with a Sandpiper profile · first public 2020-06-11 – 2020-09-30
Authors (22)
Zhu Q first · Hou Q · Huang S · Ou Q · Huo D · Vázquez-Baeza Y · Cen C · Cantu V · Estaki M · Chang H · Belda-Ferre P · Kim HC · Chen K · Knight R · Zhang J last · Ma C first · Zhang Y · Jiang S · Teng F · Jiang Y first · Aton M · Lu YY last
Downloads
PRJNA602729.csv.gz (1.7 KB) · parquet (71.9 KB) — all 20 samples, every field with route and confidence · PRJNA602729_determinations.csv.gz (3.8 KB) — 248 evidence rows