Graves' Disease gut microbiome case-control study, Haikou
34 gut metagenome samples from adults and individuals of unspecified age in Haikou, China, including autoimmune/inflammatory (Graves' Disease) cases, collected as part of a case-control study design. machine-written summary
34 samples · 34 runs · CN · Age unknown · 2020 · 6.37 Gbp / sample
One study deposited as 6 BioProjects (164 catalog samples together): PRJNA602729 · PRJNA602731 · PRJNA602732 · PRJNA638403 · PRJNA638404 · PRJNA638405 · show together
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 185 sample values (collection date, country, latitude, location locality, location region, longitude) |
| ✓ Abstract / description | 34 sample values (subject id) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| ✓ External resources | 125 sample values (age, bmi, health condition, health condition detail, sex) · from Meta2DB (LLNL) |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 30 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 25 | 74% | ||||
| country | 34 | 100% | 34 | |||
| health_condition | 25 | 74% | 25 | |||
| subject_id | 34 | 100% | 34 | |||
| collection_date | 34 | 100% | 34 | |||
| detailed_location | 34 | 100% | ||||
| latitude | 34 | 100% | 34 | |||
| location_locality | 34 | 100% | 34 | |||
| longitude | 34 | 100% | 34 | |||
| age_at_collection_days | 25 | 74% | 25 | |||
| bmi | 25 | 74% | 25 | |||
| health_condition_detail | 25 | 74% | 25 | |||
| sex | 25 | 74% | 25 | |||
| location_region | 15 | 44% | 15 |
- Compositional and genetic alterations in Graves' disease gut microbiome reveal specific diagnostic biomarkers. 2021 PMID 34079079 PMC8528855 unsure
- Cross-cohort single-nucleotide-variant profiling of gut microbiota suggests a novel gut-health assessment approach. 2023 PMID 37905808 PMC10734426 unsure
- Modeling microbiome-trait associations with taxonomy-adaptive neural networks. 2025 PMID 40158141 PMC11954268 unsure
Archive description
Ecological and evolutionary alteration in the GD intestinal microbiome part06
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.70. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host run.scientific_name · “human gut metagenome”
- body site study.title · “GD intestinal microbiome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN15195452 | age_at_collection_days | 14610.0 | R2 | 0.70 | external.meta2db source | host_age: 40 |
| SAMN15195452 | bmi | 26.15 | R2 | 0.70 | external.meta2db source | host_body_mass_index: 26.15 kilogram per meter squared |
| SAMN15195452 | collection_date | 2018-08 | R1 | 0.90 | biosample.attribute:collection_date | 2018-08 |
| SAMN15195452 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Haikou |
| SAMN15195452 | health_condition | autoimmune_inflammatory | R2 | 0.70 | external.meta2db source | graves disease |
| SAMN15195452 | health_condition_detail | graves disease | R2 | 0.70 | external.meta2db source | graves disease |
| SAMN15195452 | latitude | 20.0300 | R1 | 0.90 | biosample.attribute:lat_lon | 20.03 N 110.10 E |
| SAMN15195452 | location_locality | Haikou | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Haikou |
| SAMN15195460 | location_region | Hainan | R1 | 0.60 | biosample.attribute:lat_lon | 20.03 N 110.18 E |
| SAMN15195452 | longitude | 110.1000 | R1 | 0.90 | biosample.attribute:lat_lon | 20.03 N 110.10 E |
| SAMN15195452 | sex | male | R2 | 0.70 | external.meta2db source | host_sex: male |
| SAMN15195452 | subject_id | SAMN15195452 | R4 | 0.60 | design.one_sample_per_subject:abstract | we studied 162 gut microbiomes of mild and severe Graves' disease (GD) patients and healthy controls |
Sequencing
34 runs over 34 samples · mean 6.29 Gbp per run (median 6.37 Gbp, total 213.87 Gbp; 34 runs with a base count) · layout PAIRED 34 · platform ILLUMINA 34 · models Illumina HiSeq 4000 (34) · 88% of runs with a Sandpiper profile · first public 2020-06-13 – 2020-10-02
Authors (22)
Zhu Q first · Hou Q · Huang S · Ou Q · Huo D · Vázquez-Baeza Y · Cen C · Cantu V · Estaki M · Chang H · Belda-Ferre P · Kim HC · Chen K · Knight R · Zhang J last · Ma C first · Zhang Y · Jiang S · Teng F · Jiang Y first · Aton M · Lu YY last
Downloads
PRJNA638404.csv.gz (2.2 KB) · parquet (72.8 KB) — all 34 samples, every field with route and confidence · PRJNA638404_determinations.csv.gz (5.0 KB) — 344 evidence rows